● Spin-off University of Potsdam • Biophotonics
Miniaturized High-End
Optical Oxygen Measurement
For users, made by scientists. Non-invasive luminescent sensor beads, optodes, and the OPAL system for microfluidics, 3D cell culture, and quantitative fluorescence microscopy.
Core Technology Suite
Engineered for Micro-Scale Precision
Modular photonics solutions adaptable from conventional stage-top microscopes to industrial bioreactors.
Hardware Platform
The OPAL System
Upgrades standard fluorescence stands to quantitative oxygen measuring stations. Features digital lock-in processing to filter ambient noise and background autofluorescence.
- Photomultiplier (PMT) for camera port
- LED light source for lamp port
- Two-frequency phase modulation
- Wireless detection up to 1 m distance
- Comprehensive PC control via USB
Micro-Sensors
CPOx Sensor Beads
Immobilized phosphorescent polystyrene micro- and nanobeads (8 µm – 50 µm) designed for cellular scaffolds, hydrogels, and microfluidic channels.
- Zero oxygen consumption during sensing
- High signal-to-noise ratio & stability
- Singlet oxygen shielding (non-toxic)
- Ethanol-sterilizable & autoclavable
- Proven in organ-on-chip & 3D tissue
Fiber Probes
CPOx Micro-Optodes
Rugged optical fiber probes for minimal-invasive profiling inside tissues, plant physiology specimens, micro-bioreactors, and flow cells.
- Fast response times in seconds
- Independent of liquid stirring rate
- Reflection probe accessory available
- Wide dynamic range (0–100% vol. O₂)
Scientific Validation
Complete Publications Archive
All 26 scientific papers published with and related to the Colibri Photonics sensor technology platform.
Setup: Optical microsensor integration with perfusion bioreactors.
Microscopy: Calibrated CPOx microbeads within 3D cellular matrices.
Mapping: Oxygen gradient tracking across biological tissue sections.
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Showing all 26 peer-reviewed publications
3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation
Acta Biomaterialia, Volume 171 (2023), pp. 336–349
Optical 4D oxygen mapping of microperfused tissue models with tunable in vivo-like 3D oxygen microenvironments
Lab on a Chip, Issue 21 (2022)
Impact of Fungal Hyphae on Growth and Dispersal of Obligate Anaerobic Bacteria in Aerated Habitats
mBio, Volume 13, Issue 3 (2022)
Towards a universal application of carbon-based 3D printed sensors for electrochemical sensing
Frontiers in Bioengineering and Biotechnology 9, 611837 (2021)
Real time monitoring of oxygen uptake of hepatocytes in a microreactor using optical microsensors
Scientific Reports 10, 13700 (2020)
Microphysiological flux balance platform unravels the dynamics of drug induced steatosis
Lab on a Chip, Vol. 18, Issue 17 (2018)
Closed-loop control system for well-defined oxygen supply in micro-physiological systems
Current Directions in Biomedical Engineering, Vol. 3, Issue 2 (2017)
Hypoxia-on-a-chip
Current Directions in Biomedical Engineering, Vol. 2, Issue 1 (2016)
Universal lab-on-a-chip platform for complex, perfused 3D cell cultures
Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970516 (2016)
Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction
PNAS Proc. Natl. Acad. Sci. USA, Vol. 113, No. 16, E2231–E2240 (2016)
Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone
Archives of Toxicology (2015)
Noninvasive Oxygen Monitoring in Three-Dimensional Tissue Cultures Under Static and Dynamic Conditions
BioResearch Open Access Vol. 4.1 (2015), pp. 266–277
Spatially-resolved oxygen measurements in biological samples
LASER + PHOTONICS (2015), pp. 70–73
Ortsaufgelöste Sauerstoffmessungen in biologischen Proben
BioPhotonik 2/2014, 1-2 (2014), pp. 34–37
Intracellular O₂ Measurements via Luminescence
GIT Laboratory Journal Europe, 1-2 (2014), pp. 28–29
Optical Oxygen Micro- and Nanosensors for Plant Applications
Sensors 12 (2012), pp. 7015–7032
An Innovative Laser-Based Sensing Platform for Realtime Optical Monitoring of Oxygen
Proceedings of the 14th Joint International IMEKO TC1 + TC7 + TC13 Symposium (2011)
Distributed Fiber Optical Sensing of Molecular Oxygen with OTDR
Proc. SPIE 7726 (2010), 77260A
Regulation of Respiration and Fermentation to Control the Plant Internal Oxygen Concentration
Plant Physiology 149 (2009), pp. 1087–1098
Decreased Expression of Cytosolic Pyruvate Kinase in Potato Tubers Leads to a Decline in Pyruvate Resulting in an in Vivo Repression of the Alternative Oxidase
Plant Physiology 148 (2008), pp. 1640–1654
Intracellular pH homeostasis and serotonin-induced pH changes in Calliphora salivary glands: the contribution of V-ATPase and carbonic anhydrase
Journal of Experimental Biology 211 (2008), pp. 805–815
Minimally invasive fiber probes for optical in-vivo oxygen measurements with integrated optical thermometer
Proc. SPIE 6770 (2007), 67700V
Regulation of photosynthesis in the unicellular acidophilic red alga Galdieria sulphuraria
Plant Journal 51 (2007), pp. 500–511
Monitoring hormone-induced oxygen consumption in the salivary glands of the blowfly, Calliphora vicina, by use of luminescent microbeads
Sensors and Actuators B: Chemical 119 (2006), pp. 251–254
New challenges in biophotonics: laser-based fluoroimmuno analysis and in vivo optical oxygen monitoring
Proc. SPIE 6157 (2005), 61570E
An optical multi-frequency phase modulation method using micro-beads for measuring intracellular oxygen concentrations in plants
Biophysical Journal 89 (2005), pp. 1339–1345
Direct Correspondence
Inquiries & Contact
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Colibri Photonics GmbH
HRB 23791 P • Amtsgericht Potsdam
Office Location
Friedrich-Engels-Str. 23
14473 Potsdam, Germany
14473 Potsdam, Germany
Direct Email Address
service@colibri-photonics.com
Telecommunications
Tel: +49 331 951 40 354
Fax: +49 331 951 45 807
Fax: +49 331 951 45 807
